Der schottische Lord Mac​​beth wird von einem Hexentrio davon überzeugt, dass er der nächste König von Schottland werden wird, und seine ehrgeizige Frau Lady Macbeth unterstützt ihn bei seinen Plänen, die Macht zu ergreifen. Ehrgeiz als tragischer Fehler. Sein Handeln ohne jegliche Moral wird schließlich sein Untergang.

"A work of stark chiaroscuro and incantatory rage, Joel Coen's boldly inventive visualization of The Scottish Play is an anguished film that stares, mouth agape, at a sorrowful world undone by blind greed and thoughtless ambition. In meticulously world-weary performances, a strikingly inward Denzel Washington is the man who would be king and an effortlessly Machiavellian Frances McDormand is his Lady, a couple driven to political assassination – and deranged by guilt – after the cunning prognostications of a trio of 'weird sisters' (a virtuoso physical inhabitation by Kathryn Hunter). Though it echoes the forbidding visual designs – and aspect ratios – of Laurence Olivier's classic 1940s Shakespeare adaptations, as well as the bloody medieval madness of Kurosawa's "Throne of Blood", Coen's tale of sound and fury is entirely his own – and undoubtedly one for our moment, a frightening depiction of amoral political power-grabbing that, like its hero, ruthlessly barrels ahead into the inferno." (--- Film at Lincoln Center)